Back to Search
Start Over
Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications
- Source :
- The journal of physical chemistry. A. 121(9)
- Publication Year :
- 2017
-
Abstract
- Modern medicine has been searching for new and more efficient strategies for diagnostics and therapeutics applications. Considering this, porphyrin molecules have received great interest for applications in photodiagnostics and phototherapies, even as magnetic nanoparticles for drug-delivery systems and magnetic-hyperthermia therapy. Aiming to obtain a multifunctional system, which combines diagnostics with therapeutic functions on the same platform, the present study employed UV/vis absorption and fluorescence spectroscopies to evaluate the interaction between meso-tetrakis(p-sulfonatofenyl)porphyrin (TPPS) and maghemite nanoparticles (γ-Fe2O3). These spectroscopic techniques allowed us to describe the dynamics of coupling porphyrins on nanoparticles and estimate the number of 21 porphyrins per nanoparticle. Also, the binding parameters, such as the association constants (Ka = 8.89 × 105 M-1) and bimolecular quenching rate constant (kq = 2.54 × 1014 M-1 s-1) were obtained. These results suggest a static quenching process where the electrostatic attraction plays an essential role. The work shows that spectroscopic techniques are powerful tools to evaluate the coupling of organic molecules and nanoparticles. Besides, the system studied provides a relevant background for potential applications in bionanotechnology and nanomedicine, such as (1) nanodrug delivery system, (2) photodiagnostics/theranostics, and/or (3) a combined action of photodynamic and hyperthermia therapies, working in a synergetic way.
- Subjects :
- Modern medicine
Porphyrins
Theranostic Nanomedicine
Light
Nanoparticle
Nanotechnology
Biocompatible Materials
02 engineering and technology
010402 general chemistry
01 natural sciences
Ferric Compounds
Fluorescence
chemistry.chemical_compound
Nanobiotechnology
Physical and Theoretical Chemistry
Fluorescent Dyes
Drug Carriers
Quenching (fluorescence)
Photosensitizing Agents
021001 nanoscience & nanotechnology
Porphyrin
0104 chemical sciences
chemistry
Magnetic nanoparticles
Nanomedicine
Nanoparticles
0210 nano-technology
Subjects
Details
- ISSN :
- 15205215
- Volume :
- 121
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The journal of physical chemistry. A
- Accession number :
- edsair.doi.dedup.....3624516aa3a406116b8ff926b03ef560