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Anoxemia as the cause of death in shock
- Source :
- Medical Hypotheses. 5:699-706
- Publication Year :
- 1979
- Publisher :
- Elsevier BV, 1979.
-
Abstract
- The case is presented that both hemorrhagic and septic shock are due to an inadequate oxygen supply to mitochondria of vascular muscle cells in peripheral circulatory beds. Mitochondria disintegrate in the presence of severe hypoxia; this is a normal response which does not, per se, indicate generalized cell damage. Irreversible shock follows when appreciable numbers of the muscle mitochondria become non-functional. The ATP available from glycolysis is inadequate to resynthesize the mitochondrial apparatus and oxygen cannot be used by the damaged mitochondria to produce the needed ATP through oxidative phosphorylation. In the absence of adequate ATP, the tone of these peripheral vessels must fall, leading to irreversible systemic hypotension and death. In hemorrhagic shock, mitochondrial hypoxia of smooth muscle cells is produced by decreased perfusion of the vasa vasorum in the constricted peripheral vessels; in septic shock there is direct competition for oxygen between bacterial cytochromes and muscle mitochondria.
- Subjects :
- medicine.medical_specialty
Oxidative phosphorylation
Shock, Hemorrhagic
Mitochondrion
Biology
Adenosine Triphosphate
Neoplasms
Internal medicine
medicine
Animals
Humans
Myocyte
Glycolysis
Hypoxia
Cell damage
Septic shock
Muscle, Smooth
General Medicine
Anatomy
Hypoxia (medical)
medicine.disease
Shock, Septic
Mitochondria, Muscle
Endocrinology
medicine.anatomical_structure
Vasa vasorum
Blood Vessels
medicine.symptom
Subjects
Details
- ISSN :
- 03069877
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Medical Hypotheses
- Accession number :
- edsair.doi.dedup.....361c30445d2c001918b34ee7a54679f0