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Association between antibody response against cytomegalovirus strain-specific glycoprotein H epitopes and HLA-DR
- Source :
- Microbiology and Immunology. 53:412-416
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies.
- Subjects :
- Immunology
Congenital cytomegalovirus infection
Cytomegalovirus
Human leukocyte antigen
Antibodies, Viral
Microbiology
Epitope
Epitopes
Viral Envelope Proteins
Antibody Specificity
Neutralization Tests
Virology
HLA-DR
medicine
Humans
Antigens, Viral
HLA-DR Serological Subtypes
chemistry.chemical_classification
biology
Strain (chemistry)
HLA-DR Antigens
medicine.disease
Kidney Transplantation
Tissue Donors
Transplantation
chemistry
Antibody Formation
Cytomegalovirus Infections
biology.protein
Antibody
Glycoprotein
Subjects
Details
- ISSN :
- 13480421 and 03855600
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....361a2aec588486fa860e689996bc7f07