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Pathological aspects of bovine focal fibrogranulomatous proliferative panniculitis (Lechiguana)
- Source :
- Veterinary Research Communications. 39:39-44
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Lechiguana is a disease of cattle caused by an interaction between Dermatobia hominis warble and the bacteria Manheimia granulomatis. It is characterized by subcutaneous swellings that grow rapidly and result in death after 3 to 8 months. The objective of this paper was to investigate some vascular and fibrogenic changes of the disease at different lesion stages by histochemical and immunohistochemical techniques. A peculiar histopathological aspect observed during a proliferative phase (before treatment) was the intense vasculitis, described as degenerative and fibro-proliferative, expressed by the oncogene p53, possibly caused by the presence of bacteria in close contact with enthotelial cells, along with dense accumulations of lymphoid cells around venules. The synthesis of collagen fibers during the development of Lechiguana lesions assume a structural aspect of star arrangement with fiber radiation centers that gradually interconnect to design the Extracellular Matrix (ECM) framework, seen by Confocal Laser Scanning Microscopy (CSLM). Angiogenesis was the most characteristic finding in both proliferative and regressive stages as seen by the immunohistochemical expression of cytoskeleton proteins and von Willebrand (Factor VIII-Related Antigen). Additionally, in all tissues samples, active ECM elements like Metalloproteinases (MMPs), Tissue Inhibitors Metalloproteinases (TIMP) and Fibronectin (FN) were mainly associated to vessels structures. The extraordinary regression of exuberant granulation tissue after treatment is undoubtedly associated to the maintenance of the vascular components observed during the regressive phase.
- Subjects :
- Pathology
medicine.medical_specialty
Panniculitis
Angiogenesis
Cattle Diseases
Matrix metalloproteinase
law.invention
Lesion
Extracellular matrix
Fibrosis
Confocal microscopy
law
von Willebrand Factor
medicine
Animals
Neovascularization, Pathologic
General Veterinary
biology
Tissue Inhibitor of Metalloproteinases
General Medicine
medicine.disease
Immunohistochemistry
Extracellular Matrix
Fibronectins
Fibronectin
Cytoskeletal Proteins
Metalloproteases
biology.protein
Cattle
Collagen
medicine.symptom
Subjects
Details
- ISSN :
- 15737446 and 01657380
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Veterinary Research Communications
- Accession number :
- edsair.doi.dedup.....360dc970e71d22b2139d419d4445231c