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Relationship between DNA ploidy, antigen expression and survival in renal cell carcinoma
- Source :
- International journal of cancer. 42(5)
- Publication Year :
- 1988
-
Abstract
- Tumor ploidy and expression of renal differentiation antigens as recognized by a previously described series of monoclonal antibodies (MAbs) (RC2, RC3, RC4, RC38, RC69, RC154 and G250) were assessed in 48 renal-cell carcinomas. A positive association was found between aneuploidy and development of metastases. Aneuploid tumors showed a loss of antigen expression more frequently than diploid tumors. This difference was statistically significant for antigens recognized by RC3 and RC69. Loss of RC154 reactivity was associated with increased metastatic potential. Clinical stage was the most powerful single prognostic variable but ploidy and RC3 reactivity carried additional prognostic information.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Prognostic variable
medicine.drug_class
Aneuploidy
Biology
Monoclonal antibody
Antigen
Renal cell carcinoma
Actuarial Analysis
medicine
Humans
Stage (cooking)
Neoplasm Metastasis
Carcinoma, Renal Cell
Aged
Aged, 80 and over
Kidney
Ploidies
Antibodies, Monoclonal
DNA, Neoplasm
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Kidney Neoplasms
medicine.anatomical_structure
Oncology
Female
Ploidy
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 42
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....360c9c26dbe47add25aa819a5cb10db0