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Changes in hepatocellular carcinoma aggressiveness characteristics with an increase in tumor diameter
- Publication Year :
- 2021
-
Abstract
- Background: Hepatocellular carcinoma prognosis depends on both liver and tumor determinants, especially on maximum tumor diameter, multifocality, and presence of portal vein thrombosis, despite apparently complete tumor removal by resection or liver transplantation. Aims: To examine parameters of hepatocellular carcinoma aggressiveness as tumor size increases. Methods: A large hepatocellular carcinoma database was examined for trends in serum alpha-fetoprotein and the percentage of patients with macroscopic portal vein thrombosis or tumor multifocality. Results: A total of 13,016 hepatocellular carcinoma patients were identified having full tumor and survival data. Of these, 76.56% were male and 23.44% were female, with a median age of 64.4 years. We found that as the maximum tumor diameter increased, there was a significant trend for increased alpha-fetoprotein levels ( PConclusions: The greater fold-increases in alpha-fetoprotein and portal vein thrombosis compared with increases in maximum tumor diameter imply that hepatocellular carcinoma characteristics may change with increasing size to a more aggressive phenotype, suggesting that follow-up tumor sampling might be useful, in addition to baseline tumor sampling, for optimal therapeutic choices to be made.
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Prognosi
Settore MED/12 - GASTROENTEROLOGIA
Clinical Biochemistry
size
Pathology and Forensic Medicine
evolution
medicine
Humans
Prospective Studies
HCC
Tumor size
business.industry
Liver Neoplasms
Carcinoma
Settore MED/09 - MEDICINA INTERNA
Hepatocellular
Middle Aged
Prognosis
medicine.disease
Portal vein thrombosis
trend
Oncology
Liver Neoplasm
Hepatocellular carcinoma
Female
business
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....36046cf5b8dd54e3bc82d004f86e90f5