Back to Search
Start Over
Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?
- Source :
- Immunology Letters. 113:117-120
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- There are many viruses known to cause viral hemorrhagic fevers in humans. The mechanisms causing hemorrhage are likely to vary among viruses. Some viruses, such as Marburg virus, are directly cytopathic to infected endothelial cells, suggesting infection of endothelial cells alone can cause hemorrhage. On the other hand, there are viruses which infect endothelial cells without causing any cytopathic effects, suggesting the involvement of host immune responses in developing hemorrhage. Typical examples of these include viruses of the hantavirus species. We hypothesize that impairment of endothelial cell's defense mechanisms against cytotoxic CD8+ T cells is the mechanism of capillary leakage in hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome, which may be common to other viral hemorrhagic fevers. CD8+ T cells may be a potential target for therapy of some viral hemorrhagic fevers.
- Subjects :
- Hantavirus pulmonary syndrome
viruses
Immunology
Endothelial Cells
Vascular permeability
CD8-Positive T-Lymphocytes
Hantavirus Pulmonary Syndrome
Biology
Virology
Article
Capillary Permeability
Endothelial stem cell
Mice
Hemorrhagic Fevers
Immune system
Hemorrhagic Fever with Renal Syndrome
Animals
Humans
Immunology and Allergy
Cytotoxic T cell
CD8
Hantavirus
Subjects
Details
- ISSN :
- 01652478
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Immunology Letters
- Accession number :
- edsair.doi.dedup.....35f3c522e4980a4cdafc1731e855b69a