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Hiv-2 molecular epidemiology
- Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 46
- Publication Year :
- 2016
-
Abstract
- The Simian Immunodeficiency Virus of sooty mangabeys (SIVsmm) has been revealed to be at the origin of Human Immunodeficiency Virus type 2 (HIV-2) in humans, firstly detected from two Portuguese patients in 1986. HIV-2 is mainly restricted to West Africa where it infects up to 1 to 2 million people. HIV-2 is also present in Europe, mainly Portugal and France, India and United States of America. Two major HIV-2 groups, groups A and B, were generated by two independent transmission events involving infected sooty mangabeys from the Tai forest in Ivory Coast. Seven other HIV-2 groups have been described, but each has only been identified in one patient. To date, no subtypes have been formally described but some preliminary data suggest that HIV-2 group A may be divided in two distinct subtypes with distinct geographical origins. To date only two recombinant forms have been described: one circulating recombinant form (CRF01_AB) and one unique recombinant form. In this review, we focused mainly on molecular data available and their insights about HIV-2 origins, diversity, drug resistance and global epidemiology.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
030106 microbiology
Human immunodeficiency virus (HIV)
HIV Infections
Drug resistance
Biology
medicine.disease_cause
Microbiology
West africa
03 medical and health sciences
0302 clinical medicine
Epidemiology
Genetics
medicine
Humans
030212 general & internal medicine
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Genetic diversity
Molecular Epidemiology
Molecular epidemiology
Transmission (medicine)
Genetic Variation
Simian immunodeficiency virus
Virology
Africa, Western
Infectious Diseases
HIV-2
Subjects
Details
- ISSN :
- 15677257
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Accession number :
- edsair.doi.dedup.....35e84ee7b2e58d0027db6b4946f4caa1