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Cep44 functions in centrosome cohesion by stabilizing rootletin
- Source :
- Journal of Cell Science
- Publication Year :
- 2020
- Publisher :
- The Company of Biologists, 2020.
-
Abstract
- The centrosome linker serves to hold the duplicated centrosomes together until they separate in late G2/early mitosis. Precisely how the linker is assembled remains an open question. In this study, we identify Cep44 as a novel component of the linker in human cells. Cep44 localizes to the proximal end of centrioles, including mother and daughter centrioles, and its ablation leads to loss of centrosome cohesion. Cep44 does not impinge on the stability of C-Nap1 (also known as CEP250), LRRC45 or Cep215 (also known as CDK5RAP2), and vice versa, and these proteins are independently recruited to the centrosome. Rather, Cep44 associates with rootletin and regulates its stability and localization to the centrosome. Our findings reveal a role of the previously uncharacterized protein Cep44 for centrosome cohesion and linker assembly.<br />Highlighted Article: Maintenance of centrosome cohesion is critical for the fidelity of cell division. Here, we show that the novel protein Cep44 plays a unique role in the cohesion process through stabilizing rootletin.
- Subjects :
- Centriole
Short Report
Mitosis
Cep44
Cell Cycle Proteins
Nerve Tissue Proteins
Biology
Autoantigens
03 medical and health sciences
0302 clinical medicine
Humans
Centrioles
030304 developmental biology
Centrosome
0303 health sciences
Cell Biology
Cell biology
Cytoskeletal Proteins
Splitting
030220 oncology & carcinogenesis
Cohesion
Rootletin
Cohesion (chemistry)
Linker
Subjects
Details
- ISSN :
- 14779137 and 00219533
- Database :
- OpenAIRE
- Journal :
- Journal of Cell Science
- Accession number :
- edsair.doi.dedup.....35db15d5841da3d304cd160ff09be65e