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Evaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model
- Source :
- Pharmacology Biochemistry and Behavior. 118:30-35
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Because Δ9-tetrahydrocannabinol (THC) has been a false negative in rat intravenous self-administration procedures, the evaluation of the abuse potential of candidate cannabinoid medications has proved difficult. One lab group has successfully trained self-administration of the aminoalkylindole WIN55,212-2 in rats; however, their results have not been independently replicated. The purpose of this study was to extend their model by using a within-subjects design, with the goal of establishing a robust method suitable for substitution testing of other cannabinoids. Male Long–Evans rats were trained to self-administer WIN55,212-2 (0.01 mg/kg/infusion) on a fixed ratio 3 schedule. Dose–effect curves for WIN55,212-2 were determined, followed by vehicle substitution and a dose–effect curve with THC. WIN55,212-2 self-administration was acquired; however, substitution with THC did not maintain responding above vehicle levels. Dose-dependent attenuation by rimonabant confirmed CB1 receptor mediation of WIN55,212-2's reinforcing effects. Vehicle substitution resulted in a session-dependent decrease in responding (i.e., extinction). While this study provides systematic replication of previous studies, lack of substitution with THC is problematic and suggests that WIN55,212-2 self-administration may be of limited usefulness as a screening tool for detection of the reinforcing effects of potential cannabinoid medications. Clarification of underlying factors responsible for failure of THC to maintain self-administration in cannabinoid-trained rats is needed.
- Subjects :
- Male
Marijuana Abuse
Cannabinoid receptor
Morpholines
medicine.medical_treatment
Clinical Biochemistry
Self Administration
Naphthalenes
Pharmacology
Toxicology
Biochemistry
Article
Behavioral Neuroscience
Rimonabant
medicine
Animals
Rats, Long-Evans
Dronabinol
WIN 55,212-2
Biological Psychiatry
Cannabinoid Receptor Agonists
Behavior, Animal
Dose-Response Relationship, Drug
Cannabinoids
Extinction (psychology)
Benzoxazines
Rats
Models, Animal
Conditioning, Operant
Cannabinoid
Psychology
Self-administration
Reinforcement, Psychology
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....35c8723aa6cf37379fef8126f70fbc28