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Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer
- Source :
- Journal of Thoracic Oncology, 14(3), 377-407. International Association for the Study of Lung Cancer, Yatabe, Y, Dacic, S, Borczuk, A C, Warth, A, Russell, P A, Lantuejoul, S, Beasley, M B, Thunnissen, E, Pelosi, G, Rekhtman, N, Bubendorf, L, Mino-Kenudson, M, Yoshida, A, Geisinger, K R, Noguchi, M, Chirieac, L R, Bolting, J, Chung, J-H, Chou, T-Y, Chen, G, Poleri, C, Lopez-Rios, F, Papotti, M, Sholl, L M, Roden, A C, Travis, W D, Hirsch, F R, Kerr, K M, Tsao, M-S, Nicholson, A G, Wistuba, I & Moreira, A L 2019, ' Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer ', Journal of Thoracic Oncology, vol. 14, no. 3, pp. 377-407 . https://doi.org/10.1016/j.jtho.2018.12.005
- Publication Year :
- 2018
-
Abstract
- Since the 2015 WHO classification was introduced into clinical practice, immunohistochemistry (IHC) has figured prominently in lung cancer diagnosis. In addition to distinction of small cell versus non-small cell carcinoma, patients' treatment of choice is directly linked to histologic subtypes of non-small cell carcinoma, which pertains to IHC results, particularly for poorly differentiated tumors. The use of IHC has improved diagnostic accuracy in the classification of lung carcinoma, but the interpretation of IHC results remains challenging in some instances. Also, pathologists must be aware of many interpretation pitfalls, and the use of IHC should be efficient to spare the tissue for molecular testing. The International Association for the Study of Lung Cancer Pathology Committee received questions on practical application and interpretation of IHC in lung cancer diagnosis. After discussions in several International Association for the Study of Lung Cancer Pathology Committee meetings, the issues and caveats were summarized in terms of 11 key questions covering common and important diagnostic situations in a daily clinical practice with some relevant challenging queries. The questions cover topics such as the best IHC markers for distinguishing NSCLC subtypes, differences in thyroid transcription factor 1 clones, and the utility of IHC in diagnosing uncommon subtypes of lung cancer and distinguishing primary from metastatic tumors. This article provides answers and explanations for the key questions about the use of IHC in diagnosis of lung carcinoma, representing viewpoints of experts in thoracic pathology that should assist the community in the appropriate use of IHC in diagnostic pathology.
- Subjects :
- 0301 basic medicine
Oncology
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Neuroendocrine markers
Lung Neoplasms
Best practice
Appropriate use
TTF1
Immunohistochemistry
Lung cancer
p40
Article
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Biomarkers, Tumor
Humans
Early Detection of Cancer
NUT midline carcinoma
business.industry
Poorly differentiated
Antibodies, Monoclonal
medicine.disease
Prognosis
030104 developmental biology
030220 oncology & carcinogenesis
Practice Guidelines as Topic
business
Who classification
Subjects
Details
- Language :
- English
- ISSN :
- 15560864
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology, 14(3), 377-407. International Association for the Study of Lung Cancer, Yatabe, Y, Dacic, S, Borczuk, A C, Warth, A, Russell, P A, Lantuejoul, S, Beasley, M B, Thunnissen, E, Pelosi, G, Rekhtman, N, Bubendorf, L, Mino-Kenudson, M, Yoshida, A, Geisinger, K R, Noguchi, M, Chirieac, L R, Bolting, J, Chung, J-H, Chou, T-Y, Chen, G, Poleri, C, Lopez-Rios, F, Papotti, M, Sholl, L M, Roden, A C, Travis, W D, Hirsch, F R, Kerr, K M, Tsao, M-S, Nicholson, A G, Wistuba, I & Moreira, A L 2019, ' Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer ', Journal of Thoracic Oncology, vol. 14, no. 3, pp. 377-407 . https://doi.org/10.1016/j.jtho.2018.12.005
- Accession number :
- edsair.doi.dedup.....35c566b5505096a77af01eab7f2b285e