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Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension
- Source :
- Journal of human hypertension. 28(2)
- Publication Year :
- 2012
-
Abstract
- There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n=50) or PreE (n=50) were compared with body mass index-matched controls (n=100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy. Refereed/Peer-reviewed
- Subjects :
- Gestational hypertension
Adult
Male
medicine.medical_specialty
Sex Determination Analysis
angiotensin-(1–7)
Hypertension in Pregnancy
Blood Pressure
Gestational Age
angiotensin II
Peptidyl-Dipeptidase A
Risk Assessment
Ultrasonography, Prenatal
Preeclampsia
preeclampsia
Renin-Angiotensin System
Young Adult
angiotensin-converting enzyme
Sex Factors
Pre-Eclampsia
Pregnancy
Risk Factors
Internal medicine
Renin
gestational hypertension
Internal Medicine
medicine
Humans
Fetus
biology
business.industry
Angiotensin II
prorenin
Angiotensin-converting enzyme
Ultrasonography, Doppler
Hypertension, Pregnancy-Induced
medicine.disease
Peptide Fragments
Endocrinology
Case-Control Studies
biology.protein
Gestation
Female
Angiotensin I
business
Biomarkers
Subjects
Details
- ISSN :
- 14765527
- Volume :
- 28
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of human hypertension
- Accession number :
- edsair.doi.dedup.....35c30df0652833297096a420d4a3400d