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The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases
- Source :
- Journal of Allergy and Clinical Immunology. 138:459-467.e2
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background Chronic ocular allergic diseases such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are accompanied by serious comorbidities; however, the underlying pathogenesis remains obscure. Furthermore, diagnosing conjunctival lesions in patients with atopic dermatitis and estimating the severity in AKC are important for the treatment of ocular allergic diseases. Objective We addressed whether periostin, a novel mediator and biomarker in allergic inflammation, is involved in the pathogenesis of ocular allergic diseases and whether periostin can be a biomarker for these diseases. Methods We investigated tear periostin in patients with seasonal allergic conjunctivitis (SAC), VKC, and AKC and allergic patients without conjunctivitis and compared it with tear IL-13 and serum periostin. Furthermore, in patients with AKC, we measured tear periostin before and after topical treatment with tacrolimus. Results Tears from patients with ocular allergic disease showed significantly high periostin levels than did tears from allergic patients without conjunctivitis and from patients with AKC, VKC, and SAC in descending order. Tear periostin was associated with serious comorbidities such as large papilla formation and corneal damage in AKC, although both tear IL-13 and serum periostin had little to no such abilities. Furthermore, after topical tacrolimus treatment, tear periostin tended to decrease in most patients with AKC along with their clinical improvement. Conclusions Periostin produced in conjunctival tissues stimulated by IL-13 may contribute to the pathogenesis of ocular allergic diseases. Furthermore, tear periostin can be potentially applied as a biomarker to diagnose conjunctivitis in allergic patients and to evaluate disease severity as well as the efficacy of treatments in AKC.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Eye Diseases
Immunology
Enzyme-Linked Immunosorbent Assay
Periostin
Allergic inflammation
03 medical and health sciences
0302 clinical medicine
Hypersensitivity
Humans
Immunology and Allergy
Medicine
Conjunctivitis, Allergic
Interleukin-13
business.industry
Disease Management
Epithelial Cells
Atopic dermatitis
Fibroblasts
medicine.disease
Dermatology
eye diseases
Tacrolimus
030104 developmental biology
030228 respiratory system
Case-Control Studies
Tears
Chronic Disease
Interleukin 13
Biomarker (medicine)
Female
sense organs
business
Cell Adhesion Molecules
Vernal keratoconjunctivitis
Biomarkers
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....35ba91920920eecea2c75fe39a03897e