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Prefilter and Postfilter Cysteine/Cystine and Copper Concentrations in Pediatric Parenteral Nutrition Solutions
- Source :
- Journal of Parenteral and Enteral Nutrition. 16:460-463
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- Pediatric amino acid products contain lower concentrations of methionine and require the addition of L-cysteine HCl just before infusion. Reports of a potential interaction between cysteine and copper, a routine addition to parenteral nutrition solutions, have appeared in the literature. This study serially evaluated cysteine/cystine and copper concentrations pre- and postfilter (0.22 microns) in two parenteral nutrition formulations prescribed for normal fluid (NF) or fluid-restricted (FR) pediatric patients. Solutions were infused via a peristaltic pump in vitro for 24 hours. Pre- and postfilter samples were obtained immediately after the infusion began (time 0) and at 1, 2, 3, 4, 8, 12, 16, 20, and 24 hours during the infusion. At 24 hours pre- and postfilter, cysteine/cystine were quantitated at 87.3% and 85% of the initial concentrations, respectively, for the NF solution and 92% and 91.5% for the FR solution. Pre- and postfilter copper was quantitated at 87.5% and 92.5% of the initial concentrations, respectively, for the NF solution and 88.2% and 95.2% for the FR solution. The 24 hour area under the curve for cysteine/cystine was 88.4% for the NF solution and 96.4% for the FR solution. For copper, the area under the curve for the NF solution was 99% and 96.7% for the FR solution. There was no visual evidence of incompatibility or precipitation. We conclude that copper-containing parenteral nutrition solutions with L-cysteine HCl added immediately before infusion are relatively stable after compounding and infusion over 24 hours.
- Subjects :
- Parenteral Nutrition
Time Factors
030309 nutrition & dietetics
Cystine
Medicine (miscellaneous)
chemistry.chemical_element
Parenteral Nutrition Solutions
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Stability
Humans
Drug Interactions
Cysteine
chemistry.chemical_classification
0303 health sciences
Nutrition and Dietetics
Chromatography
Methionine
Area under the curve
Copper
Amino acid
Parenteral nutrition
Biochemistry
chemistry
030211 gastroenterology & hepatology
Filtration
Subjects
Details
- ISSN :
- 19412444 and 01486071
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Parenteral and Enteral Nutrition
- Accession number :
- edsair.doi.dedup.....35b2e1b0af1fbae2b7f74bdfe8718515