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The effect of certain choline esters on the chemoceptor activity in the carotid body
- Source :
- Acta physiologica Scandinavica. 31(2-3)
- Publication Year :
- 1954
-
Abstract
- Summary. Minute amounts of a number of choline esters, injected into the carotid artery, elicited increased chemoceptor activity of the sinus nerve. The effect was especially pronounced for acetyl-, acetylthio- and butyrylthiocholine; propionyl- and butyrylcholine were slightly less active, whereas for benzoyl-, acetyl-β-methyl-and succinyl-choline somewhat larger doses were required. After local treatment of the carotid body with the anticholinesterase mintacol the responses to acetyl-, propionyl-, butyryl-and benzoyl-choline were greatly increased, but the sensitivity to the thiocholines was lowered. Oxygen lack led to a stronger stimulation after mintacol than before. DFP, applied locally, also led to a sensitization of the cheinoceptors to acetyl-, butyryl-, propionyl- and benzoylcholine as well as for oxygen lack. Acetylcholine was again an exception. The results support the view that acetylcholine or related substances are involved in the initiation of the chemoceptive discharge from the carotid body.
- Subjects :
- medicine.medical_specialty
Carotid Body
Physiology
Stimulation
Esters
Butyrylthiocholine
Choline
chemistry.chemical_compound
medicine.anatomical_structure
Endocrinology
Benzoylcholine
chemistry
Biochemistry
Parasympathomimetics
Internal medicine
medicine
lipids (amino acids, peptides, and proteins)
Carotid body
Butyrylcholine
Sensitization
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 00016772
- Volume :
- 31
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Acta physiologica Scandinavica
- Accession number :
- edsair.doi.dedup.....35a7e3323ada6ddc813227c3ec270c98