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The effect of certain choline esters on the chemoceptor activity in the carotid body

Authors :
Y. Zotterman
G. Liljestrand
Source :
Acta physiologica Scandinavica. 31(2-3)
Publication Year :
1954

Abstract

Summary. Minute amounts of a number of choline esters, injected into the carotid artery, elicited increased chemoceptor activity of the sinus nerve. The effect was especially pronounced for acetyl-, acetylthio- and butyrylthiocholine; propionyl- and butyrylcholine were slightly less active, whereas for benzoyl-, acetyl-β-methyl-and succinyl-choline somewhat larger doses were required. After local treatment of the carotid body with the anticholinesterase mintacol the responses to acetyl-, propionyl-, butyryl-and benzoyl-choline were greatly increased, but the sensitivity to the thiocholines was lowered. Oxygen lack led to a stronger stimulation after mintacol than before. DFP, applied locally, also led to a sensitization of the cheinoceptors to acetyl-, butyryl-, propionyl- and benzoylcholine as well as for oxygen lack. Acetylcholine was again an exception. The results support the view that acetylcholine or related substances are involved in the initiation of the chemoceptive discharge from the carotid body.

Details

ISSN :
00016772
Volume :
31
Issue :
2-3
Database :
OpenAIRE
Journal :
Acta physiologica Scandinavica
Accession number :
edsair.doi.dedup.....35a7e3323ada6ddc813227c3ec270c98