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Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats
- Source :
- Neuroscience Bulletin. 34:457-464
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Gamma band oscillation (GBO) and sensory gating (SG) are associated with many cognitive functions. Ketamine induces deficits of GBO and SG in the prefrontal cortex (PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that (1) ketamine administration increased GBO power in the PFC in rats differently in the low- and high-dose groups; (2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and (3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-018-0208-8) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Time Factors
Physiology
Statistics as Topic
Prefrontal Cortex
Rats, Sprague-Dawley
03 medical and health sciences
Basal (phylogenetics)
0302 clinical medicine
Internal medicine
medicine
Animals
Gamma Rhythm
Ketamine
Wakefulness
Prefrontal cortex
Analysis of Variance
Sensory gating
Dose-Response Relationship, Drug
Chemistry
General Neuroscience
Electroencephalography
General Medicine
Human physiology
Sensory Gating
Rats
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Acoustic Stimulation
Original Article
Sleep Stages
Excitatory Amino Acid Antagonists
Gamma band
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 19958218 and 16737067
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Neuroscience Bulletin
- Accession number :
- edsair.doi.dedup.....35a5a538b9472df166bd080d5ce6bcfe