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Enhancement by Carbachol of Transmitter Release from Motor Nerve Terminals
- Source :
- Proceedings of the National Academy of Sciences. 71:1489-1492
- Publication Year :
- 1974
- Publisher :
- Proceedings of the National Academy of Sciences, 1974.
-
Abstract
- In the endplates of rat phrenic nerve-diaphragm, application of the acetylcholine-like compound, carbachol, causes a marked increase in transmitter release, as measured electrophysiologically using miniature endplate potential frequency. Washing out of carbachol reverses the increase in frequency. The ability of carbachol to increase transmitter release is greatly enhanced by perfusion of the preparation with Ringer solution containing elevated K + . At concentrations of carbachol greater than 30 μM, the onset of the postjunctional blocking action of carbachol is too rapid and obscures the increase in miniature potential frequency. The rate of increase in transmitter release is dependent on the concentration of carbachol applied and can be antagonized by d -tubocurarine (10-60 nM) and other blocking compounds. These findings, in contrast to previous reports, indicate that cholinergic nerve endings, like adrenergic nerve endings, respond to applied acetylcholine-like drugs with measurable increases in transmitter output.
- Subjects :
- Male
Carbachol
Neuromuscular Junction
Action Potentials
Motor nerve
In Vitro Techniques
Neurotransmission
Synaptic Transmission
Parasympathetic nervous system
Parasympathetic Nervous System
medicine
Animals
Phrenic nerve
Motor Neurons
Nerve Endings
Multidisciplinary
Dose-Response Relationship, Drug
Neurosecretion
Chemistry
Osmolar Concentration
Anatomy
Acetylcholine
Stimulation, Chemical
Rats
Biological Sciences: Physiology
Phrenic Nerve
medicine.anatomical_structure
Potassium
Biophysics
Cholinergic
Free nerve ending
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....35a533dc0f326354e1bf11022278a35e