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Simvastatin and Losartan Differentially and Synergistically Inhibit Atherosclerosis in Apolipoprotein E-/- Mice
- Source :
- Korean Circulation Journal
- Publication Year :
- 2012
- Publisher :
- The Korean Society of Cardiology, 2012.
-
Abstract
- BACKGROUND AND OBJECTIVES Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on atherosclerosis in apolipoprotein E (apoE)(-/-) mice. MATERIALS AND METHODS Apolipoprotein E(-/-) mice were fed a high-fat, high-cholesterol (HFHC) diet for 12 weeks, with and without simvastatin (40 mg/kg) and/or losartan (20 mg/kg). The mice were divided into 5 groups and were fed as follows: regular chow (control diet, n=5), HFHC diet (n=6), HFHC diet with losartan (n=6), HFHC diet with simvastatin (n=6), and HFHC diet with both losartan and simvastatin (n=6). RESULTS Losartan treatment in apoE(-/-) mice significantly decreased atherosclerotic lesion areas in whole aortic strips stained with Oil Red O. The plaque area measured at the aortic sinus level was reduced significantly by 17% (HFHC; 346830.9±52915.8 µm(2) vs. HFHC plus losartan; 255965.3±74057.7 µm(2), p
- Subjects :
- Apolipoprotein E
medicine.medical_specialty
Simvastatin
Pharmacology
Losartan
Lesion
Internal medicine
Aortic sinus
Internal Medicine
medicine
Inhibitory effect
business.industry
Macrophage infiltration
Atherosclerosis
Mice, knockout
medicine.anatomical_structure
Endocrinology
Models, animal
lipids (amino acids, peptides, and proteins)
Original Article
medicine.symptom
Aortic strips
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17385555 and 17385520
- Volume :
- 42
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Korean Circulation Journal
- Accession number :
- edsair.doi.dedup.....3595041151552486567c3a804b36f559