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Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia
- Source :
- Virulence, Virulence, Taylor & Francis, 2010, 1 (3), pp.185-187. ⟨10.4161/viru.1.3.11317⟩, Virulence, 2010, 1 (3), pp.185-187. ⟨10.4161/viru.1.3.11317⟩
- Publication Year :
- 2010
-
Abstract
- International audience; Aspergillus fumigatus is the most ubiquitous and the most threatful airborne fungal pathogen. In the atmosphere, there is thousands of conidia/m (3) originating from more than hundred fungal genera, which enter the host through the respiratory system and are eliminated by the innate immune defences. But how do A. fumigatus conidia survive long enough in the lung withstanding the host killing reactions? We demonstrated recently the role of the spore-surface rodlet layer made up of hydrophobic protein (hydrophobin) in preventing their recognition by the immune system. Upon removal of this rodlet layer by chemical, genetic or biological means, the resulting morphotypes were immunostimulatory in effect, confirming the essentiality of the role of the rodlet layer for the fungal survival in vivo.
- Subjects :
- Microbiology (medical)
Hydrophobin
Surface Properties
Immunology
Air Microbiology
Virulence
Microbiology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Aspergillus fumigatus
Conidium
Fungal Proteins
03 medical and health sciences
Immune system
Cell Wall
Humans
skin and connective tissue diseases
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
030304 developmental biology
0303 health sciences
Phagocytes
Innate immune system
biology
030306 microbiology
fungi
Fungal genetics
Spores, Fungal
biology.organism_classification
Spore
Infectious Diseases
Immune System
Parasitology
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 21505608 and 21505594
- Volume :
- 1
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Virulence
- Accession number :
- edsair.doi.dedup.....358b1e525dcd857daa9fabf6a5778a59