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Impact of Human Leukocyte Antigen-Associated Polymorphisms on Variability of HIV-1 Accessory and Regulatory Proteins
- Source :
- AIDS Research and Human Retroviruses. 37:962-966
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- HIV-1 escapes by acquiring mutations that differentially influence the course of infection. Unlike HIV-1 structural and enzymatic proteins, it remains elusive what extent the host immune-mediated selection pressure influences the variability of the accessory (Vif, Vpu, Vpr, and Nef) and regulatory (Tat and Rev) proteins. To address this, we analyzed the viral sequences encoding accessory and regulatory proteins from 446 human leukocyte antigen (HLA)-typed, chronically HIV-1 subtype B-infected, and treatment-naive individuals in Japan. We observed that Vpu and Vpr were the most and least polymorphic proteins with the average Shannon entropy scores of 0.63 and 0.38, respectively. Phylogenetically corrected methods identified a total of 161 HLA-associated polymorphisms; whereby Nef and Vpu had the highest (26.6%) and lowest (1.2%) proportion of amino acid sites associated with HLA-class I alleles, respectively. These results add further insight on the role of HLA-mediated selection pressure on HIV-1 sequence polymorphisms of HIV-1 accessory and regulatory proteins.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Human Immunodeficiency Virus Proteins
Immunology
Human immunodeficiency virus (HIV)
virus diseases
HIV Infections
Human leukocyte antigen
Biology
medicine.disease_cause
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Infectious Diseases
Enzyme
chemistry
HLA Antigens
Virology
HIV-1
medicine
Humans
Viral Regulatory and Accessory Proteins
nef Gene Products, Human Immunodeficiency Virus
030212 general & internal medicine
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....358a7700f981b7b321777f578f60daaf