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Exposure Levels and Contributing Factors of Various Arsenic Species and Their Health Effects on Korean Adults
- Source :
- Archives of environmental contamination and toxicology. 82(3)
- Publication Year :
- 2021
-
Abstract
- Arsenic is a human carcinogen. Data on urinary arsenic species analyses of Koreans is limited. This study evaluated the arsenic exposure level, contributing factors, and health effects in Korean adults. Dietary intake information and urine samples were obtained from 2,044 participants. Arsenic exposure was assessed based on urinary concentrations of arsenic species, such as inorganic arsenic, As(III) and As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB), using high-performance liquid chromatography with inductively coupled plasma mass spectrometry, followed by determination of biomarkers, malondialdehyde and c-peptide. The geometric mean concentrations were 30.9 ㎍/L for the sum of inorganic arsenic and their metabolites, and 84.7 ㎍/L for the total sum of arsenic measured. Urinary concentrations of arsenic species were influenced by age, inhabitant area (inland or coastal), and seafood intake, which was positively correlated with inorganic arsenic, DMA, and AsB. Rice intake was positively correlated with inorganic arsenic and its metabolites but not with AsB. Additionally, malondialdehyde and c-peptide levels were significantly associated with urinary concentrations of various arsenic species. Seafood and rice are major sources of organic/inorganic arsenic exposure in Korean adults; however, it is necessary to evaluate whether their overconsumption could have a potentially detrimental effect on human health.
- Subjects :
- inorganic chemicals
Adult
integumentary system
business.industry
Health, Toxicology and Mutagenesis
chemistry.chemical_element
Oryza
General Medicine
Toxicology
Pollution
Arsenic
chemistry
Environmental health
Republic of Korea
Medicine
Cacodylic Acid
Humans
business
Chromatography, High Pressure Liquid
Subjects
Details
- ISSN :
- 14320703
- Volume :
- 82
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Archives of environmental contamination and toxicology
- Accession number :
- edsair.doi.dedup.....3585a8ddf4e52ae5af3499feec9e3c4b