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Antibiotic resistant bacteria and resistance genes in biofilms in clinical wastewater networks
- Source :
- International journal of hygiene and environmental health. 222(4)
- Publication Year :
- 2018
-
Abstract
- Increasing isolation rates of resistant bacteria in the last years require identification of potential infection reservoirs in healthcare facilities. Especially the clinical wastewater network represents a potential source of antibiotic resistant bacteria. In this work, the siphons of the sanitary installations from 18 hospital rooms of two German hospitals were examined for antibiotic resistant bacteria and antibiotic residues including siphons of showers and washbasins and toilets in sanitary units of psychosomatic, haemato-oncological, and rehabilitation wards. In addition, in seven rooms of the haemato-oncological ward, the effect of 24 h of stagnation on the antibiotic concentrations and MDR (multi-drug-resistant) bacteria in biofilms was evaluated. Whereas no antibiotic residues were found in the psychosomatic ward, potential selective concentrations of piperacillin, meropenem and ciprofloxacin were detected at a rehabilitation ward and ciprofloxacin and trimethoprim were present at a haemato-oncology ward. Antibiotic resistant bacteria were isolated from the siphons of all wards, however in the psychosomatic ward, only one MDR strain with resistance to piperacillin, third generation cephalosporins and quinolones (3MRGN) was detected. In contrast, the other two wards yielded 11 carbapenemase producing MDR isolates and 15 3MRGN strains. The isolates from the haemato-oncological ward belonged mostly to two specific rare sequence types (ST) (P. aeruginosa ST823 and Enterobacter cloacae complex ST167). In conclusion, clinical wastewater systems represent a reservoir for multi-drug-resistant bacteria. Consequently, preventive and intervention measures should not start at the wastewater treatment in the treatment plant, but already in the immediate surroundings of the patient, in order to minimize the infection potential.
- Subjects :
- medicine.drug_class
Multi drug resistant bacteria
Antibiotics
Drug resistance
010501 environmental sciences
Wastewater
01 natural sciences
Meropenem
Microbiology
03 medical and health sciences
0302 clinical medicine
Antibiotic resistance
Drug Resistance, Multiple, Bacterial
medicine
030212 general & internal medicine
0105 earth and related environmental sciences
Bacteria
business.industry
Public Health, Environmental and Occupational Health
Hospitals
Anti-Bacterial Agents
Multiple drug resistance
Ciprofloxacin
Genes, Bacterial
Bathroom Equipment
business
medicine.drug
Piperacillin
Environmental Monitoring
Subjects
Details
- ISSN :
- 1618131X
- Volume :
- 222
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of hygiene and environmental health
- Accession number :
- edsair.doi.dedup.....357a896a935d9e2b6ef4e3ab8e58f868