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Dose-dependent effect of niceritrol on plasma lipoprotein-a
- Source :
- Scandinavian Journal of Clinical and Laboratory Investigation. 56:359-365
- Publication Year :
- 1996
- Publisher :
- Informa UK Limited, 1996.
-
Abstract
- Lipoprotein-a, Lp(a), is a variant form of low density lipoprotein (LDL) that contains apolipoprotein-a, whose structure has 75-85% homology with plasminogen. Elevated plasma levels of Lp(a) are considered to be one of the independent risk factors for cardiovascular disease. We studied the effects of niceritrol, a nicotinic acid derivative, on plasma Lp(a) levels in 72 patients with hypercholesterolaemia. The dose of niceritrol was increased every 4 weeks, from 750 to 1500 and then to 2250 mg day-1. The final dose was adjusted to obtain a plasma cholesterol level less than 5.69 mmol l-1. Niceritrol led to significant decreases in plasma levels of median Lp(a), from 16.1 mg dl-1 (interquartile intervals, 8.7 to 32.8) to 11.1 mg dl-1 (interquartile intervals, 6.6 to 21), the mean reduction rate being 17.6%. In the group with pretreatment Lp(a) levels of over 20 mg dl-1, Lp(a) decreased by 10.0, 22.0 and 31.8% at the doses of 750, 1500, and 2250 mg day-1, respectively. In the group with levels less than 20 mg dl-1, only the dose of 2250 mg day-1 was effective in the reduction of Lp(a). The results suggest that the reduction of Lp(a) was dependent on the dose of niceritrol and on the pretreatment level of Lp(a). In conclusion, niceritrol is effective, in a dose-dependent manner, for reducing Lp(a) levels.
- Subjects :
- Male
Plasma lipoprotein
medicine.medical_specialty
Niceritrol
Clinical Biochemistry
Hyperlipidemias
chemistry.chemical_compound
Interquartile range
Internal medicine
Blood plasma
medicine
Humans
Aged
Hypolipidemic Agents
Dose-Response Relationship, Drug
biology
Cholesterol
General Medicine
Lipoprotein(a)
Middle Aged
Dose–response relationship
Endocrinology
chemistry
Low-density lipoprotein
biology.protein
Female
medicine.drug
Subjects
Details
- ISSN :
- 15027686 and 00365513
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Clinical and Laboratory Investigation
- Accession number :
- edsair.doi.dedup.....35718cf9d617fc34a5b36f74bd618179