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The European Community Directive on the classification and labeling of chemicals for reproductive toxicity
- Source :
- Journal of occupational and environmental medicine. 37(8)
- Publication Year :
- 1995
-
Abstract
- The classification and labeling of dangerous substances was first introduced in 1967 in the European Community with Council Directive 67/548/EEC, known as the Dangerous Substances Directive. The Sixth Amendment to this directive in 1979 introduced a notification procedure for new chemicals and a requirement for labeling chemicals for toxicity. Three special categories for labeling were for carcinogenicity, mutagenicity, and teratogenicity. The teratogenicity classification was restricted to chemicals inducing teratogenic effects in the classical sense of the word, ie, producing only gross structural malformations. Discussions by expert advisors to the European Commission over several years led to a widening of concern in this area of toxicology and, under the recent Seventh Amendment,1 the classification of “teratology” has been changed to “toxic to reproduction.” This includes adverse effects on fertility, pre- and postnatal development, and lactation, and encompasses not only structural but also functional deficits. This will bring about a major change in the testing requirements to allow adequate classification of chemicals for these other aspects of reproductive toxicity.
- Subjects :
- Male
European community
business.industry
Reproduction
Public Health, Environmental and Occupational Health
Directive
Hazardous Substances
Toxicology
Teratogens
Pregnancy
Environmental health
Occupational Exposure
Medicine
Humans
European commission
Female
European Union
Reproductive toxicity
business
Breast feeding
Council directive
Subjects
Details
- ISSN :
- 10762752
- Volume :
- 37
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of occupational and environmental medicine
- Accession number :
- edsair.doi.dedup.....357163ce5baf47f155948e6c66ec3c2f