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Promising anti-diabetes mellitus activity in rats of β-amyrin palmitate isolated from Hemidesmus indicus roots
- Source :
- European Journal of Pharmacology. 734:77-82
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- While evaluating the toxicity of the tuberous root extracts of Hemidesmus indicus, a traditional medicinal plant, the glucose lowering property of the root was observed by the investigators. Therefore, it was thought of interest to isolate the anti-hyperglycemic principle from the root and determine its utility to develop an anti-diabetes mellitus medicine. The active principle was isolated from H. indicus root extract by anti-hyperglycemic activity guided chromatographic techniques. Glucose tolerance test in rats was used to evaluate the anti-hyperglycenic property. Anti-diabetes mellitus property was evaluated in alloxan-induced diabetic rats as well as streptozotocin-induced (type-2 model) diabetic rats. The active principle was isolated and identified with spectral data as β-amyrin palmitate. Although it is a known compound, its presence in H. indicus is not known previously. It was observed for the first time that β-amyrin palmitate has remarkable anti-hyperglycemic activity in orally glucose loaded rats. Further, interestingly, it exhibited excellent anti-diabetes mellitus activity in both alloxan-diabetic and streptozotocin-diabetic rats at a very low concentration (50µg/kg body weight). One of the mechanisms of action of β-amyrin palmitate appears to be blocking the entry of glucose from the intestine. β-Amyrin palmitate is very promising to develop a medicine for diabetes for combination therapy and/or mono-therapy.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Amyrin
Combination therapy
Pharmacology
Plant Roots
Diabetes Mellitus, Experimental
Hemidesmus indicus
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Oleanolic Acid
Rats, Wistar
Spectral data
Volume concentration
Hemidesmus
Glucose tolerance test
medicine.diagnostic_test
biology
business.industry
Body Weight
Organ Size
Glucose Tolerance Test
medicine.disease
biology.organism_classification
Rats
Endocrinology
Liver
chemistry
Toxicity
business
Glycogen
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 734
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....3570ddd3770801825d92fb2da774a4f2