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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
- Source :
- Molecules, Vol 25, Iss 2970, p 2970 (2020), Molecules
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.
- Subjects :
- Computer science
High-throughput screening
Point-of-Care Systems
Microfluidics
Pharmaceutical Science
02 engineering and technology
Review
infectious diseases
01 natural sciences
Analytical Chemistry
lcsh:QD241-441
lcsh:Organic chemistry
Limit of Detection
Drug Discovery
Food Quality
Humans
microfluidic paper-based analytical devices
immunoassay
Physical and Theoretical Chemistry
environmental monitoring
food quality control
010401 analytical chemistry
Organic Chemistry
biomarkers
Paper based
Equipment Design
Microfluidic Analytical Techniques
drug analysis
021001 nanoscience & nanotechnology
0104 chemical sciences
High-Throughput Screening Assays
Chemistry (miscellaneous)
Clinical diagnosis
Molecular Medicine
Biochemical engineering
Drug analysis
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 2970
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....3570b167c74e916e811d4272c3caa183