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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Authors :
Mai Nguyet Ly
Kwanwoo Shin
Oh-Sun Kwon
Siraprapa Boobphahom
Nadnudda Rodthongkum
Nayoon Pyun
Veasna Soum
Source :
Molecules, Vol 25, Iss 2970, p 2970 (2020), Molecules
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

Details

Language :
English
ISSN :
14203049
Volume :
25
Issue :
2970
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....3570b167c74e916e811d4272c3caa183