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Simplified fabrication of laminated paper-based analytical device (LPAD) with color-palette mobile app for analysis of salicylic acid in pharmaceutical products
- Source :
- Analytical Sciences. 38:533-540
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- In this work, we present for the first time, a simplified fabrication of a laminated paper-based analytical device (LPAD) with a free-mobile app, Palette Cam, for image analysis. A filter paper is cut in a rectangular shape (9 × 3 cm) and placed between a top laminating sheet with punched holes and a bottom laminating sheet. The holes allow accessibility of liquid on the paper. Thermal lamination is then employed to complete the fabrication of LPAD. Our simplified design reduces a tedious alignment of small pieces of paper to the holes. We demonstrated the LPAD with an analysis of salicylic acid in pharmaceutical products. Each 4 μL of ferric reagent and sample was dispensed on the LPAD. Smartphone was used to capture images. The RGB (red green blue) color intensity from the Palette Cam was converted into a logarithm color ratio. Our LPAD is simplified, cost-effective and able to be a portable device.
Details
- ISSN :
- 13482246 and 09106340
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Analytical Sciences
- Accession number :
- edsair.doi.dedup.....356e556867a45599b6ae8272d308f3bb