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Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 104:76-81
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- We describe a case of CEOT of the mandible, which underwent malignant transformation and developed metastatic tumors of the lung after repeated local recurrence. The primary tumor revealed typical histological features of benign CEOT showing sheets of polyhedral epithelial cells associated with abundant eosinophilic amyloid-like materials. On the other hand, the locally recurrent tumors had malignant features, such as increased nuclear pleomorphism with frequent mitotic figures and vascular invasion of tumor cells, as well as increased proliferative activity assessed by immunostaining for Ki-67. Chemotherapy was carried out against the pulmonary metastatic lesions, which showed a drastic response after 3 courses of intravenous administration of cisplatin (CDDP). To date, a total of 6 courses of CDDP and 6 courses of nedaplatin (CDGP) have been done, and the remaining pulmonary tumors have been dormant. This suggests that platinum derivatives could be a chemotherapeutic agent of choice against this rare tumor.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Lung Neoplasms
Organoplatinum Compounds
Antineoplastic Agents
Mandible
Malignant transformation
chemistry.chemical_compound
Humans
Medicine
Nedaplatin
General Dentistry
Cisplatin
Bone Transplantation
Lung
business.industry
Odontogenic tumor
Cancer
Middle Aged
Odontogenic Cyst, Calcifying
medicine.disease
Primary tumor
Calcifying epithelial odontogenic tumor
Radiography
Mandibular Neoplasms
medicine.anatomical_structure
Otorhinolaryngology
chemistry
Surgery
Neoplasm Recurrence, Local
Oral Surgery
business
medicine.drug
Subjects
Details
- ISSN :
- 10792104
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- Accession number :
- edsair.doi.dedup.....356b3e00967de7e388e7b432f0b5e8f6