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Activation of the neuroendocrine response in heart failure: Adaptive or maladaptive process?
- Source :
- Cardiovascular Drugs and Therapy. 10:623-629
- Publication Year :
- 1996
- Publisher :
- Springer Science and Business Media LLC, 1996.
-
Abstract
- Congestive heart failure is a clinical syndrome in which the capacity of the heart to maintain cardiac output is impaired. As a consequence, blood pressure is threatened and endocrine and paracrine mechanisms are activated to preserve circulatory homeostasis and to maintain blood pressure. At terminal stages, a complex multiorgan syndrome develops with severe pump failure, intense systemic vasoconstriction, and avid water and sodium retention. Increasing evidence points to humoral circulating or locally synthesized substances as one of the causes of the terminal consequences of heart failure. Therefore, the hypothesis that the syndrome of heart failure is, at least in part, a humoral disease has developed and is obtaining scientific credibility. Consequently, the neuroendocrine response to heart failure is no longer viewed as a compensatory beneficial mechanism. Instead, we have learned through the years that pharmacological treatment aimed at reducing the effect of the neuroendocrine response is indeed clinically and prognostically advantageous for the patient.
- Subjects :
- ACE inhibitors
Atrial natriuretic peptide
Heart failure
Hormones
Renin angiotensin aldosterone
Tumor necrosis factor alpha
medicine.medical_specialty
Sympathetic nervous system
Cardiac output
Sympathetic Nervous System
Heart disease
Blood Pressure
Renin-Angiotensin System
Internal medicine
Renin–angiotensin system
medicine
Humans
Pharmacology (medical)
Heart Failure
Pharmacology
business.industry
General Medicine
medicine.disease
Adaptation, Physiological
Neurosecretory Systems
Body Fluids
medicine.anatomical_structure
Blood pressure
ACE inhibitor
Immunology
Circulatory system
Cardiology
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
medicine.drug
Subjects
Details
- ISSN :
- 15737241 and 09203206
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Drugs and Therapy
- Accession number :
- edsair.doi.dedup.....356aa7bed078b6f696a32b8a2c6236da