Back to Search
Start Over
Impaired autoregulation of blood flow in subcutaneous tissue of long-term Type 1 (insulin-dependent) diabetic patients with microangiopathy: an index of arteriolar dysfunction
- Source :
- Diabetologia. 28:711-717
- Publication Year :
- 1985
- Publisher :
- Springer Science and Business Media LLC, 1985.
-
Abstract
- Autoregulation of blood flow in subcutaneous tissue was studied at the level of the lateral malleolus in eight long-term Type 1 (insulin-dependent) diabetic patients with clinical microangiopathy, eight short-term Type 1 diabetic patients without clinical microangiopathy and seven healthy control subjects. Blood flow was measured by the local 133Xenon washout technique. Mean arterial blood pressure was reduced by a maximum of 23 mmHg by elevating the limb above heart level and elevating to a maximum of 70 mmHg by head-up tilt; in the latter position venous pressure was kept constant and low by activation of the leg muscle vein pump (heel raising). Mean arterial blood pressure was thus varied between 60 and 160 mmHg. In normal and short-term diabetic subjects blood flow remained within 10% of control values during the changes in arterial blood pressure. In six of the eight Type 1 diabetic patients with clinical microangiopathy, autoregulation of blood flow was impaired, blood flow changing ap proximately 20% per 10 mmHg change in arterial blood pressure; the slope of the autoregulation curves was significantly higher compared with the two control groups (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Hemodynamics
Blood Pressure
Basement Membrane
Diabetic Neuropathies
Arteriole
Internal medicine
medicine.artery
Internal Medicine
medicine
Homeostasis
Humans
Autoregulation
Vein
Skin
Type 1 diabetes
business.industry
Microangiopathy
Arteries
Blood flow
medicine.disease
Arterioles
Diabetes Mellitus, Type 1
Blood pressure
medicine.anatomical_structure
Endocrinology
Regional Blood Flow
Cardiology
Female
business
Diabetic Angiopathies
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....35664d5b5a38182505e74158f268d9b6