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Epilepsy in children with periventricular leukomalacia
- Source :
- Clinical Neurology and Neurosurgery. 115:2046-2048
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Objective We aimed to analyze the development of epilepsy in a patient group with periventricular leukomalacia followed at a tertiary pediatric neurology center. Patients and methods The study included 108 children aged between 2 and 8 years with radiologically proven periventricular leukomalacia who had been regularly observed at the Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Neurology outpatient clinic between January 2006 and December 2011. Results Neonatal seizures were reported in 22 patients (20.3%), 14 of whom developed epilepsy. A significant correlation was found between neonatal seizures and prematurity and newborn asphyxia ( p = 0.013 and p = 0.010, respectively). Epilepsy developed in 35 patients (32.4%), history of neonatal seizures and more severe loss of white matter, periventricular hyperintensity and corpus callosum involvement were found to be correlated with epilepsy ( p = 0.001, p = 0.004, p = 0.016, and p = 0.004, respectively). The most common seizure pattern observed was generalized tonic clonic seizures ( n = 13) and complex partial seizures ( n = 11). Those with focal EEG findings had a significantly better neurodevelopmental and cognitive level than those with multifocal/generalized EEG findings ( p = 0.024). Seizures continued with varying frequency in 14 epileptic patients (40%) despite antiepileptic treatment. Conclusion Almost a third of patients with periventricular leukomalacia develop epilepsy that can be intractable in substantial part. Neonatal seizures and severe MRI findings are important clues that can indicate the development of epilepsy in these patients.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Leukomalacia, Periventricular
Fetal Hypoxia
Corpus callosum
White matter
Epilepsy
Risk Factors
Sepsis
medicine
Humans
Outpatient clinic
Child
Neonatal seizure
Cerebral Hemorrhage
Asphyxia
Periventricular leukomalacia
business.industry
Infant, Newborn
Electroencephalography
General Medicine
Prognosis
medicine.disease
Magnetic Resonance Imaging
Epilepsy, Benign Neonatal
medicine.anatomical_structure
Epilepsy in children
Child, Preschool
Anticonvulsants
Female
Surgery
Neurology (clinical)
medicine.symptom
business
Infant, Premature
Subjects
Details
- ISSN :
- 03038467
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Clinical Neurology and Neurosurgery
- Accession number :
- edsair.doi.dedup.....3562b520c9034ccd9bde207979ede05c