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Clinical and cortical decline in the aphasic variant of Alzheimer’s disease
- Publication Year :
- 2019
-
Abstract
- Introduction Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation. Methods Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA Aβ+ and PPA Aβ− ), an imaging biomarker of underlying Alzheimer's disease. Results Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA Aβ+ . The PPA Aβ+ group also showed greater decline in performance on most language tasks. There was no obligatory relationship between the logopenic PPA variant and amyloid status. Effect sizes from quantitative MRI data were more robust than neuropsychological metrics. Discussion Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non–Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Amyloid
Imaging biomarker
Epidemiology
Neuropathology
Disease
Neuropsychological Tests
Article
Primary progressive aphasia
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Atrophy
Developmental Neuroscience
Alzheimer Disease
Internal medicine
medicine
Humans
Longitudinal Studies
030304 developmental biology
0303 health sciences
Amyloid beta-Peptides
business.industry
Health Policy
Neurodegeneration
Neuropsychology
Brain
respiratory system
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
Aphasia, Primary Progressive
Positron-Emission Tomography
Disease Progression
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....355845143ebb461ba9df37c8c99d3a66