Viscosity-sensitive thiolated gold nanoclusters with diffusion-controlled emission for intracellular viscosity imaging

A unique diffusion-dependent emission phenomenon of gold nanoclusters was discovered, and can be regulated by the variation in viscosity and temperature. This specific property of gold nanoclusters was further used for viscosity monitoring in live cells, and the results demonstrated that gold nanoclusters are capable of real-time monitoring the abnormal viscosity change inside the cells.