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Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma
- Source :
- American journal of surgery. 218(5)
- Publication Year :
- 2018
-
Abstract
- We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC).Sixty-one patients who underwent surgery for ICC during 2000-2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs).Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio).Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sarcopenia
Hepatic resection
Serum albumin
Gastroenterology
Cholangiocarcinoma
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Hepatectomy
Humans
In patient
Intrahepatic Cholangiocarcinoma
Aged
Psoas Muscles
Retrospective Studies
Aged, 80 and over
Third lumbar vertebra
biology
business.industry
Skeletal muscle
General Medicine
Middle Aged
medicine.disease
Skeletal muscle mass
Prognosis
medicine.anatomical_structure
Bile Duct Neoplasms
030220 oncology & carcinogenesis
biology.protein
030211 gastroenterology & hepatology
Surgery
Female
business
Subjects
Details
- ISSN :
- 18791883 and 20002017
- Volume :
- 218
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- American journal of surgery
- Accession number :
- edsair.doi.dedup.....3532c3265815f58660a712949bdb4d05