Back to Search Start Over

Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome

Authors :
Candela Caballero
Eusebi Chiner
Maria F. Troncoso
Rafael Golpe
Francisco Javier Ribas-Solis
Babak Mokhlesi
Juan F. Masa
Mónica González
Cristina Senent
Pilar de Lucas
Silvia Gómez
Auxiliadora Romero
María Luz Alonso-Álvarez
José N. Sancho-Chust
M-Ángeles Sánchez-Quiroga
Jesús Sanchez-Gómez
Ana Santiago-Recuerda
Sergi Marti
José M. Benítez
Josefa Díaz-de-Atauri
Miguel Merchan
Ana Obeso
Jose M. Marin
Begoña Gallego
Joaquín Terán-Santos
Estrella Ordax
Carlos Egea
Jesús Muñoz-Méndez
Olga Cantalejo
Mónica Bengoa
Teresa Gomez-Garcia
Maria-Ángeles Martinez-Martinez
Jaime Corral
Emilia Barrot
Soledad López-Martín
Mercedes Pallero
Mª Antonia Ramón
Elena Ojeda
Trinidad Díaz-Cambriles
Santiago J. Carrizo
Garcia-Ledesma E
Nicolás González-Mangado
Source :
Chest, r-FISABIO. Repositorio Institucional de Producción Científica, instname, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Publication Year :
2016
Publisher :
AMER COLL CHEST PHYSICIANS, 2016.

Abstract

Background Obesity hypoventilation syndrome (OHS) is associated with a high burden of cardiovascular morbidity (CVM) and mortality. The majority of patients with OHS have concomitant OSA, but there is a paucity of data on the association between CVM and OSA severity in patients with OHS. The objective of our study was to assess the association between CVM and OSA severity in a large cohort of patients with OHS. Methods In a cross-sectional analysis, we examined the association between OSA severity based on tertiles of oxygen desaturation index (ODI) and CVM in 302 patients with OHS. Logistic regression models were constructed to quantify the independent association between OSA severity and prevalent CVM after adjusting for various important confounders. Results The prevalence of CVM decreased significantly with increasing severity of OSA based on ODI as a continuous variable or ODI tertiles. This inverse relationship between OSA severity and prevalence of CVM was seen in the highest ODI tertile and it persisted despite adjustment for multiple confounders. Chronic heart failure had the strongest negative association with the highest ODI tertile. No significant CVM risk change was observed between the first and second ODI tertiles. Patients in the highest ODI tertile were younger, predominantly male, more obese, more hypersomnolent, had worse nocturnal and daytime gas exchange, lower prevalence of hypertension, better exercise tolerance, and fewer days hospitalized than patients in the lowest ODI tertile. Conclusions In patients with OHS, the highest OSA severity phenotype was associated with reduced risk of CVM. This finding should guide the design of future clinical trials assessing the impact of interventions aimed at decreasing cardiovascular morbidity and mortality in patients with OHS. Trial Registry Clinicaltrial.gov; No.: NCT01405976 ; URL: www.clinicaltrials.gov

Details

ISSN :
00123692
Database :
OpenAIRE
Journal :
Chest, r-FISABIO. Repositorio Institucional de Producción Científica, instname, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Accession number :
edsair.doi.dedup.....35263581ad294c41ff065a75e8e6993c