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The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo
- Source :
- Clinica Chimica Acta. 362:161-169
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Background Although retinoids have potential efficacy in aged skin, their side effect (skin irritation) remains a clinical problem. We designed a novel synthetic retinoid, seletinoid G, by using computer-aided molecular modeling, and investigated its effects on the expression of extracellular matrix proteins in human skin in vivo. Methods Twenty-three subjects were tested on the buttocks using 4-day occlusive application of seletinoid G and all- trans retinoic acid ( t RA). Skin irritation after topical application was quantified by the degree of erythema and cutaneous blood flow. The expression of extracellular matrix proteins and interstitial collagenase (MMP-1) in skin biopsies was investigated by immunohistochemical staining and Western blotting. Results The topical application of seletinoid G under occlusion induced no skin irritation in contrast to t RA, which caused severe erythema. The topical treatment with seletinoid G increased the expressions of type I procollagen, tropoelastin, and fibrillin-1, and reduced MMP-1 in old skin in vivo. Seletinoid G was found to inhibit not only the UV-induced decrease of type I procollagen but the UV-induced increase of MMP-1 and c-Jun protein in young skin in vivo. Conclusions Seletinoid G is a novel synthetic retinoid, which has little the side effect of skin irritation after topical application. Seletinoid G can repair altered connective tissue in old skin and inhibit UV-induced collagen deficiency in young skin.
- Subjects :
- Adult
Male
medicine.medical_specialty
Erythema
Proto-Oncogene Proteins c-jun
medicine.drug_class
Clinical Biochemistry
Retinoic acid
Connective tissue
Tretinoin
Human skin
Pharmacology
Biochemistry
Extracellular matrix
Retinoids
chemistry.chemical_compound
In vivo
medicine
Humans
Retinoid
Aged
Pyrans
Extracellular Matrix Proteins
Molecular Structure
integumentary system
Biochemistry (medical)
Dioxolanes
General Medicine
Dermatology
Skin Aging
medicine.anatomical_structure
Gene Expression Regulation
chemistry
Interstitial collagenase
Female
Matrix Metalloproteinase 1
medicine.symptom
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 362
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....3525db18837dfb141cddf3d8ad6b5343