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Iron-Catalyzed Tandem Three-Component Alkylation: Access to α-Methylated Substituted Ketones
- Source :
- Organic Letters, Organic Letters, American Chemical Society, 2019, 21 (9), pp.3057-3061. ⟨10.1021/acs.orglett.9b00630⟩
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- International audience; The borrowing hydrogen strategy has been applied in the synthesis of α-branched methylated ketones via a tandem three-component reaction catalyzed by a diaminocyclopentadienone iron tricarbonyl complex. Various alkyl and aromatic methyl ketones underwent dialkylation with various primary alcohols and methanol as alkylating agents in mild reaction conditions and good yields. Deuterium labeling experiments suggested that the benzylic alcohol was the hydrogen source in this tandem process.
- Subjects :
- chemistry.chemical_classification
Hydrogen
Tandem
[CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry
Chemistry
Organic Chemistry
Borrowing hydrogen
chemistry.chemical_element
[CHIM.CATA]Chemical Sciences/Catalysis
[CHIM.MATE]Chemical Sciences/Material chemistry
Alkylation
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Deuterium
Methanol
Physical and Theoretical Chemistry
Alkyl
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....351c5af494e2c6ae15a39747f88a2068