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Critical hematocrit and oxygen partial pressure in the beating heart of pigs
- Source :
- Hiebl, B.; Mrowietz, C.; Ploetze, K.; Matschke, K.; Jung, F.: Critical hematocrit and oxygen partial pressure in the beating heart of pigs. In: Microvascular Research. Vol. 80 (2010) 3, 389-393. (DOI: 10.1016/j.mvr.2010.06.002), ResearcherID
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- In cardiac surgery the substitution of lost blood volume by plasma substitutes is a common therapeutical approach. None of the currently available blood substitutes has a sufficient oxygen transport capacity. This can limit the functional integrity of the myocardium known as highly oxygen consumptive. The study was aimed to get information about the minimal hematocrit, also known as critical hematocrit (cHct), which guarantees a stable and adequate oxygen partial pressure in the myocardium (pO2). In adult female pigs (n = 7) the hematocrit was reduced by isovolemic blood dilution with an intravenous infusion of isotonic 4% gelatine polysuccinate solution, The substituted blood volume ranged between 3000 ml and 7780 ml (mean: 5254 ± 1672 ml). In all animals the pO2 of the myocardium of the beating heart and of the resting skeletal muscle increased until blood dilution resulted in a Hct decrease down to 15%. Further blood dilution resulted in a decrease of the pO2. Only after the Hct was < 10% the pO2 was lower than before blood dilution and accompanied by a lethal ischemia of the myocardium. These data indicate a cHct of about 10% in the pig animal model.
- Subjects :
- medicine.medical_specialty
Time Factors
Swine
Partial Pressure
Myocardial Ischemia
Plasma Substitutes
Ischemia
Blood Pressure
Blood volume
Hematocrit
Biochemistry
Oxygen Consumption
Heart Rate
Heart rate
medicine
Animals
ddc:610
Infusions, Intravenous
Muscle, Skeletal
Hemodilution
medicine.diagnostic_test
business.industry
Myocardium
Oxygen transport
Succinates
Cell Biology
medicine.disease
Cardiac surgery
Oxygen
Blood pressure
Anesthesia
cardiovascular system
Gelatin
Female
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 00262862
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Microvascular Research
- Accession number :
- edsair.doi.dedup.....351aebb0d34a5092c9fc1bad8a7d9d0b