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Combination and inducible adjuvants targeting nucleic acid sensors
- Source :
- Current Opinion in Pharmacology. 41:104-113
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Innate immune sensing of nucleic acids derived from invading pathogens or tumor cells via pattern recognition receptors is crucial for mounting protective immune responses against infectious disease and cancer. Recently, discovery of tremendous amounts of nucleic acid sensors as well as identification of natural and synthetic ligands for these receptors revealed the potential of adjuvants targeting nucleic acid sensing pathways for designing efficacious vaccines. Especially, current data indicated that unique adjuvants targeting TLR9 and stimulator of interferon genes (STING)-dependent cytosolic nucleic acid sensing pathways along with the combinations of already existing adjuvants are promising candidates for this purpose. Here, we review current vaccine adjuvants targeting nucleic acid sensors and their modes of action.
- Subjects :
- 0301 basic medicine
Pharmacology
Innate immune system
Chemistry
Pattern recognition receptor
Membrane Proteins
TLR9
Communicable Diseases
03 medical and health sciences
030104 developmental biology
Immune system
Adjuvants, Immunologic
Biochemistry
Infectious disease (medical specialty)
Neoplasms
Nucleic Acids
Receptors, Pattern Recognition
Toll-Like Receptor 9
Stimulator of interferon genes
Drug Discovery
Nucleic acid
Humans
Receptor
Subjects
Details
- ISSN :
- 14714892
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Pharmacology
- Accession number :
- edsair.doi.dedup.....3516b78ec04fb42ebe2908df9105bb98