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Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study
- Source :
- Journal of Affective Disorders. 260:653-659
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases. Methods FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups. Results Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions. Limitations The potential effects of medicine, age, course of disease and handedness on results could not be ignored. Conclusions Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.
- Subjects :
- Adult
Male
medicine.medical_specialty
Bipolar Disorder
Precuneus
Prefrontal Cortex
Audiology
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Gyrus
Parietal Lobe
mental disorders
medicine
Humans
Paracentral lobule
First episode
Depressive Disorder, Major
Resting state fMRI
business.industry
Brain
Precentral gyrus
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Frontal Lobe
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
Superior frontal gyrus
Major depressive disorder
Female
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 260
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....351347549e20ecfa09e57b41e829d46d