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In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe
- Publication Year :
- 2016
-
Abstract
- A handheld probe enables retinal imaging in children. Enabled by adaptive optics, retinal photoreceptor cell imaging is changing our understanding of retinal structure1,2 and function3,4, as well as the pathogenesis of numerous ocular diseases5. To date, use of this technology has been limited to cooperative adult subjects due to the size, weight and inconvenience of the equipment, thus excluding study of retinal maturation during human development. Here, we report the design and operation of a handheld probe that can perform both scanning laser ophthalmoscopy and optical coherence tomography of the parafoveal photoreceptor structure in infants and children without the need for adaptive optics. The probe, featuring a compact optical design weighing only 94 g, was able to quantify packing densities of parafoveal cone photoreceptors and visualize cross-sectional photoreceptor substructure in children with ages ranging from 14 months to 12 years. The probe will benefit paediatric research by improving the understanding of retinal development, maldevelopment and early onset of disease during human growth.
- Subjects :
- genetic structures
01 natural sciences
Article
010309 optics
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Optics
Optical coherence tomography
0103 physical sciences
Medicine
Adaptive optics
Early onset
medicine.diagnostic_test
business.industry
Retinal
eye diseases
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Scanning laser ophthalmoscopy
Biophotonics
Cellular resolution
chemistry
030221 ophthalmology & optometry
Retinal imaging
sense organs
business
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3510abe971bd9a84237c7192b2205415