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The Beauty of a Visualized Peroxo-diiron(III) Intermediate

Authors :
Gerhard Grüber
Source :
Structure. (5):805-806
Publisher :
Elsevier Ltd.

Abstract

Deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are essential for hypusination of eukaryotic translation initiation factor 5A (eIF-5A). In this issue, Han et al. use X-ray crystallograpy and UV/Vis and Mossbauer spectroscopy to provide insights into the fundamental mechanism of the hypusination of eIF-5A and a peroxo intermediate state.

Details

Language :
English
ISSN :
09692126
Issue :
5
Database :
OpenAIRE
Journal :
Structure
Accession number :
edsair.doi.dedup.....350d0e74504280a1e6ac7f58419b405a
Full Text :
https://doi.org/10.1016/j.str.2015.04.010