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Reduced Renal Reabsorption of 1,5-Anhydro-D-Glucitol in Diabetic Rats and Mice
- Source :
- The Journal of Biochemistry. 102:1599-1607
- Publication Year :
- 1987
- Publisher :
- Oxford University Press (OUP), 1987.
-
Abstract
- A stable amount, approximately 60 micrograms, of 1,5-anhydro-D-glucitol (AG) was detected in the 24-h-urine of normal young rats fed ad libitum. Upon administration of streptozotocin (STZ), this amount was temporarily elevated to as much as 1.1 mg and AG was concomitantly removed from the circulation. The plasma AG level stayed almost null thereafter while the acutely elevated urinary AG excretion declined within 24 h to another stable excretion level that was three times as high as that of the untreated rats. In contrast, glucosuria developed much more slowly in the drug-treated rats. Normal rats and mice retained exogenous [14C]AG to a considerable extent and the radioactivity was distributed all over the body. Only a marginal fraction of the radioactivity was excreted as expired CO2. The radio-activities retained in the body and excreted into the urine were mostly attributed to unmetabolized AG. The observations of AG's metabolic stability and its relatively low level of leakage into urine suggested the concept of effective renal AG reabsorption. On the other hand, the rats with STZ-induced diabetes and NOD-mice with spontaneously developed diabetes retained little of the radioactive AG in their bodies; most of the injected radioactivity was recovered in the urine within 24 h. This observation was interpreted as due to reduced renal AG reabsorption in these animals. The concept of reduction in renal AG reabsorption in diabetes could account for the reduced plasma AG level generally observed in human diabetic cases.
- Subjects :
- Male
medicine.medical_specialty
Urinary system
Urine
Deoxyglucose
Biology
Kidney
Biochemistry
Gas Chromatography-Mass Spectrometry
Absorption
Diabetes Mellitus, Experimental
Excretion
Mice
Glycosuria
Internal medicine
Deoxy Sugars
medicine
Animals
Tissue Distribution
Carbon Radioisotopes
Molecular Biology
Chromatography, High Pressure Liquid
Mice, Inbred ICR
Reabsorption
Kidney metabolism
Renal Reabsorption
Rats, Inbred Strains
General Medicine
Streptozotocin
Rats
Endocrinology
medicine.anatomical_structure
medicine.drug
Subjects
Details
- ISSN :
- 17562651 and 0021924X
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- The Journal of Biochemistry
- Accession number :
- edsair.doi.dedup.....350be8b13e285d64ea2ee36f596db4aa