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Lack of Association of the CD247 SNP rs2056626 with Systemic Sclerosis in Han Chinese

Authors :
Xiaodong Zhou
Shervin Assassi
Dongyi He
Yi Wang
Yuanhui Gu
Lin Yi
Xinjian Guo
Hejian Zou
Jiucun Wang
Gang Guo
Syeling Lai
Wenzhen Tu
Hongyi Li
Rong Xiao
Maureen D. Mayes
Li Yang
Wenyu Wu
Source :
The Open Rheumatology Journal
Publication Year :
2014
Publisher :
Bentham Science Publishers Ltd., 2014.

Abstract

Systemic sclerosis (SSc) is a complex disease involving multiple genetic factors. A recent genome-wide association study (GWAS) indicated that CD247 was strongly associated with SSc, which was subsequently confirmed in a SSc cohort of European population. However, genetic heterogeneity in different ethnic populations may significantly impact the complex trait of SSc. The studies herein aimed to examine whether the SSc-associated SNP rs2056626 of CD247 identified in Caucasian is also associated with Han Chinese SSc. A Han Chinese cohort consisting of 387 SSc patients and 523 healthy controls were examined in the studies. TaqMan assays were performed to examine the SNP. Exact p-values were obtained (Fisher’s test) from 2x2 tables of allele counts and disease status. The results showed that there was no association between rs2056626 of CD247 and SSc or any SSc subtypes of Han Chinese. The negative results are important in understanding genetics of SSc in different ethnic populations, which further suggest complex nature of genetics of SSc.

Details

ISSN :
18743129
Volume :
8
Database :
OpenAIRE
Journal :
The Open Rheumatology Journal
Accession number :
edsair.doi.dedup.....34f1cff6f5b3ced32202b4df710c3909