Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome

To the editor: There is mounting evidence from the study of animal models of human disorders of defective ribosome biogenesis, including Diamond-Blackfan anemia and Treacher Collins syndrome, that ribosomal stress leads to activation of the p53 pathway.[1][1][⇓][2]–[3][3] Stabilization of p53