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Bactericidal and Sterilizing Activities of Several Orally Administered Combined Regimens against Mycobacterium ulcerans in Mice
- Source :
- Antimicrobial Agents and Chemotherapy. 52:1912-1916
- Publication Year :
- 2008
- Publisher :
- American Society for Microbiology, 2008.
-
Abstract
- Treatment with rifampin-clarithromycin or moxifloxacin-clarithromycin for 8 weeks displayed promising bactericidal activity against Mycobacterium ulcerans in mice; none of the mice treated with rifampin-clarithromycin relapsed, whereas 59% of those treated with moxifloxacin-clarithromycin relapsed after treatment was stopped. The bactericidal and sterilizing activities of the five-times-weekly (5/7) administration of 5 mg of rifapentine/kg of body weight, either alone or in combination, were virtually identical to those of the corresponding regimens with 10 mg of rifampin/kg of body weight; however, because of the long half-life of rifapentine, accumulation of the drug after 5/7 administration is a concern. The bactericidal activity of 20 mg/kg rifapentine in monotherapy or 20 mg/kg rifapentine in combination with 150 mg/kg streptomycin or 200 mg/kg moxifloxacin administered twice weekly was as effective as the corresponding regimens containing 10 mg/kg rifampin administered 5/7, suggesting that Buruli ulcer might be treated with intermittently administered rifapentine-containing combinations.
- Subjects :
- Buruli ulcer
Moxifloxacin
Antitubercular Agents
Colony Count, Microbial
Mycobacterium Infections, Nontuberculous
Pharmacology
Microbiology
Mice
Oral administration
Clarithromycin
polycyclic compounds
medicine
Animals
Experimental Therapeutics
Pharmacology (medical)
Antibacterial agent
Aza Compounds
Mice, Inbred BALB C
Mycobacterium ulcerans
biology
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Rifapentine
Anti-Bacterial Agents
Treatment Outcome
Infectious Diseases
Streptomycin
Quinolines
Drug Therapy, Combination
Female
Rifampin
Fluoroquinolones
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....34eabcb3c7ff18099afea8e426f67560