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Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice
- Source :
- Neurotherapeutics
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Subarachnoid hemorrhage (SAH) remains a life-threatening disease, and early brain injury (EBI) is an important cause of poor outcomes. The authors have reported that periostin, a matricellular protein, is one of key factors of post-SAH EBI. Clarithromycin (CAM) is a worldwide antibiotic that can inhibit periostin expression. This study aimed to investigate whether CAM suppressed EBI after experimental SAH, focusing on blood–brain barrier (BBB) disruption, an important pathology of EBI. C57BL/6 male adult mice underwent endovascular perforation SAH modeling (n = 139) or sham operation (n = 30). Different dosages (25, 50, or 100 mg/kg) of CAM or the vehicle (n = 16, 52, 13, and 58, respectively) were randomly administered by an intramuscular injection 5 min after SAH induction. Post-SAH 50 mg/kg CAM treatment most effectively improved neurological scores and brain water content at 24 and 48 h and reduced immunoglobulin G extravasation at 24 h compared with vehicle-treated SAH mice (p
- Subjects :
- Male
0301 basic medicine
Subarachnoid hemorrhage
Perforation (oil well)
Periostin
Pharmacology
Neuroprotection
Mice
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Clarithromycin
Animals
Medicine
Pharmacology (medical)
cardiovascular diseases
Dose-Response Relationship, Drug
business.industry
Matricellular protein
Brain
Subarachnoid Hemorrhage
medicine.disease
Extravasation
nervous system diseases
Mice, Inbred C57BL
Blot
Neuroprotective Agents
030104 developmental biology
Blood-Brain Barrier
Brain Injuries
Original Article
Neurology (clinical)
business
Cell Adhesion Molecules
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 18787479 and 19337213
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Neurotherapeutics
- Accession number :
- edsair.doi.dedup.....34e9389c49d65830da9af0ab227c13ec