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Randomized trial of topical periocular castor oil treatment for blepharitis
- Source :
- The ocular surface. 19
- Publication Year :
- 2019
-
Abstract
- To evaluate the effects of topical castor oil application to the eyelids on ocular surface and tear film parameters in patients with blepharitis.Twenty-six participants (14 females, 12 males; mean ± SD age, 38 ± 21 years) with clinical signs of blepharitis were enrolled in a prospective, investigator-masked, randomized, paired-eye trial. A 100% cold pressed castor oil formulation (Lotus Garden Botanicals, Biddeford, ME, USA) was applied to the eyelids of one eye (randomized), twice daily for 4 weeks. Ocular surface characteristics, symptoms, and tear film parameters were assessed at baseline and day 28.Baseline measurements did not differ between treated and control eyes (all p 0.05). A significant reduction in OSDI symptomology score was observed following the four-week treatment period (p = 0.001). Clinical improvements in eyelid margin thickening, telangiectasia, eyelash matting, madarosis, cylindrical dandruff, and lid wiper epitheliopathy were limited to treated eyes (all p 0.01), while greater decreases in staphylococcal and seborrheic eyelash crusting were observed in treated than control eyes (both p 0.05). No adverse events were reported during the treatment period.Topical castor oil application effected significant improvements in ocular surface signs and symptoms in patients with blepharitis. The favourable therapeutic profile would suggest that castor oil demonstrates promise as a potential treatment for blepharitis, and support the conduct of further efficacy trials with longer follow up.ACTRN12618000856213.
- Subjects :
- Adult
Male
medicine.medical_specialty
Castor Oil
business.product_category
Adolescent
Meibomian gland
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
Randomized controlled trial
law
medicine
Humans
Prospective Studies
Blepharitis
Telangiectasia
biology
business.industry
Eyelids
Madarosis
Middle Aged
biology.organism_classification
medicine.disease
Dermatology
eye diseases
Ophthalmology
medicine.anatomical_structure
Tears
030221 ophthalmology & optometry
Female
sense organs
Eyelid
medicine.symptom
Eyelash
business
030217 neurology & neurosurgery
Demodex
Subjects
Details
- ISSN :
- 19375913
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- The ocular surface
- Accession number :
- edsair.doi.dedup.....34cf47f06663e5aa48aaedfb89fd7b16