Back to Search
Start Over
Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors?
- Source :
- Postępy Higieny i Medycyny Doświadczalnej, Vol 66, Iss 855199, Pp 696-701 (2012), Scopus-Elsevier, ResearcherID
- Publication Year :
- 2012
- Publisher :
- Index Copernicus International S.A., 2012.
-
Abstract
- Introduction Folic acid (FA) may delay the formation of atherosclerotic lesions. Increased plasma levels of von Willebrand factor (VWF) are observed in cardiovascular disease, which leads to higher risk of thrombosis. Fibrinogen (Fb) is a well-documented risk factor of cardiovascular disease. The aim of this study was to analyze the effect of FA supplementation on the Fb, VWF and C-reactive protein (CRP) plasma concentrations in subjects with atherosclerosis risk factors. Material/methods The study enrolled 124 Caucasian individuals (60 M, 64 F) with atherosclerosis risk factors--family history of premature ischaemic stroke, arterial hypertension, dyslipidaemia, overweight and obesity, cigarette smoking and low physical activity. The participants were asked to take FA in the low dose of 0.4 mg/24 h for three months. Results After FA supplementation a significant reduction of the VWF concentrations in females (76.6 vs 72.3%; p=0.028) and in males (75.5 vs 66.9%; p=0.001) was observed. Among women and men with dyslipidaemia concentrations of VWF decreased after FA supplementation (76.8% vs 69.6%; p=0.003 and 76.7% vs 67.8%; p=0.001 respectively). Among females and males with BMI ≥25 kg/m² concentrations of VWF decreased only in men (77.6% vs 66.5%; p=0.001). In female and male smokers supplementation of FA decreased VWF concentrations (82.5% vs 74.4%; p=0.012 and 76.6% vs 69.5%; p=0.036 respectively). Discussion The results of our study suggest that there is an effect of FA supplementation on VWF concentrations in subjects with atherosclerosis risk factors.
- Subjects :
- Adult
Male
Microbiology (medical)
medicine.medical_specialty
lcsh:Medicine
Comorbidity
Overweight
coagulation factors
Fibrinogen
Young Adult
Folic Acid
Von Willebrand factor
Risk Factors
Internal medicine
von Willebrand Factor
medicine
Humans
Obesity
Risk factor
Dyslipidemias
biology
business.industry
Smoking
C-reactive protein
lcsh:R
medicine.disease
Atherosclerosis
Thrombosis
Blood Coagulation Factors
Stroke
C-Reactive Protein
Infectious Diseases
Endocrinology
Coagulation
Dietary Supplements
haemostasis
biology.protein
Female
medicine.symptom
business
CRP
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17322693 and 00325449
- Volume :
- 66
- Issue :
- 855199
- Database :
- OpenAIRE
- Journal :
- Postępy Higieny i Medycyny Doświadczalnej
- Accession number :
- edsair.doi.dedup.....34cbf865018317e62426a6a577feaf94