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Chromosomal Insertion and Amplification of Human Papillomavirus 16 DNA Sequences in a Cell Line of Argyrophil Small Cell Carcinoma of the Uterine Cervix
- Source :
- Japanese Journal of Cancer Research : Gann
- Publication Year :
- 1991
- Publisher :
- Wiley, 1991.
-
Abstract
- The chromosomal location of human papillomavirus (HPV) 16 DNA sequences integrated in a cell line derived from argyrophil small cell carcinoma of the uterine cervix was determined by means of fluorescence in situ hybridization (FISH). The HPV 16 DNA sequences were integrated near a fragile site and the location of the c‐myc oncogene at 8q24.1. Amplification of the integrated viral sequences resulted in an abnormally banded region. The amplified HPV 16 DNA sequences were also detected in every interphase nucleus by FISH.
- Subjects :
- Cancer Research
medicine.medical_specialty
Silver
Cervial carcinoma
Genes, myc
Uterine Cervical Neoplasms
Biology
DNA sequencing
Cell Line
chemistry.chemical_compound
Nucleic acid thermodynamics
Chromosomal Insertion
medicine
Humans
Carcinoma, Small Cell
Papillomaviridae
Human papillomavirus (HPV 16)
Fluorescent Dyes
medicine.diagnostic_test
Chromosome Fragile Sites
Chromosome Fragility
Fluorescence in situ hybridization
Chromosomal fragile site
Gene Amplification
Cytogenetics
Nucleic Acid Hybridization
biology.organism_classification
Virology
Molecular biology
female genital diseases and pregnancy complications
Chromosome Banding
Oncology
chemistry
DNA, Viral
DNA Transposable Elements
Female
Rapid Communication
DNA
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 09105050
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Cancer Research
- Accession number :
- edsair.doi.dedup.....34c1762709026e6eebf72ad3eff21e98
- Full Text :
- https://doi.org/10.1111/j.1349-7006.1991.tb01857.x